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Development of Artificial Blood Vessel Using Bacterial Cellulose (Abstract)

Kwon Mun Hyok¹ , Han Gyong Ae²

¹ Department of Pediatric Orthopaedics, Pyongyang Medical University Hospital, DPR Korea

² Department of Biochemistry, KIM IL SUNG University, DPR Korea

 

Abstract

Background: Development of new artificial blood vessel is very important issue in vascular surgery because vascular injuries are growing higher and especially, most of vascular substitutes are not available in the surgery related to small diameter vessel less than 6mm. The aim of this study was to review basic characteristics for application of bacterial cellulose into artificial blood vessel.

Materials and Methods: We used Acetobacter xylinum 10 for production of bacterial cellulose and manufactured several devices to gain tubular bacterial cellulose and investigated its effectiveness mechanically and pathologically.

Results: Suitable carrier was 4µm-thick polyethylene for high cellulose production and suitable culture period was18 days. Young’s modulus (GPa) of tubular Bacterial Cellulose gained in new culture device was 13.6 GPa and strain (%) was five times higher than cellophan. Tubular Bacterial Cellulose (BC) had a quite low porosity (0.00107 ± 0.00011 ml/mm²· min·120mmHg) and thickness of  capsule around the graft was peak (42.2±0.84 µm) in the 60 days after implantation and significantly thinner than PTFE throughout investigated period and change of inflammatory cell numbers had same trend with that of capsule.

Conclusion: Our results suggest that tubular bacterial cellulose has suitable mechanical properties and good biocompatibility for application of artificial blood vessel.

Key words: bacterial cellulose, artificial blood vessel, biocompatibility

 

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