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Putative criteria for predicting spontaneous regression of prenatally diagnosed thoraco-abdominal cystic lesions

Jean Fran├žois Lecompte, Geraldine Hery, Guillaume Gorincour, Nicole Philip, Pascal de Lagausie

Hopital Timone Enfant, Marseille, France

 

Abstract

Purpose: Cystic lesions are common findings during prenatal ultrasonography but their pre- and post-natal prognosis is difficult to establish since some regress spontaneously. The purpose of this study was to identify putative criteria to predict regression of partially or completely cystic lesions detected by prenatal ultrasound.
Methods: Prenatal ultrasound features of thoracic or abdominal cystic lesions were retrospectively analyzed. Ovarian and urological lesions were not included in this study.
Results: A total of 57 cystic lesions were studied. Thirty-six lesions including 10 abdominal (43.5%) and 26 thoracic (76.5%) lesions required surgical resection (p=0.02). Ten persistent lesions after birth were only monitored. Eleven lesions including 8 abdominal (34.7%) and 3 thoracic (8.8%) regressed prenatally (p=0.02). Regressing abdominal lesions consistently presented as solitary lesions with a homogenous aspect. Only one abdominal lesion showed a multilobulated aspect. Two regressing thoracic lesions were purely cystic and one presented a heterogeneous aspect.
Conclusion: Regression of cystic lesions detected by prenatal ultrasound scan was more likely for lesions in abdominal (mainly adrenal or splenic lesions) than thoracic locations. The likelihood of regression was highest for purely cystic abdominal lesions.